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Importantly, the pathophysiological consequences of elevated NET components in the follicular microenvironment are supported by parallel evidence: multiple studies link increased oxidative stress and inflammatory mediators in follicular fluid to reduced oocyte competence, lower fertilization rates, and poorer embryo quality in women with PCOS, providing a biologically plausible pathway by which NET-derived DNA, histones, and proteases could impair gamete quality and fertilization success [55]

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[19:03] Andrew Huberman Are they happy with that effect

In all cases, frequency is determined by the prescribing physician based on the patient's baseline IGF-1 levels, age, body composition goals, and response to initial cycles

Importantly, any strategy to counteract the toxicity of chemotherapy must avoid compromising the ability of chemotherapy to reduce tumour growth